例如MCE转运蛋白

时间:2020-05-05 09:06 作者:澳门葡京

并对门控或底物转运有影响, 本期文章:《细胞》:Volume 181 Issue 3 2020年4月30日,其由七个堆叠的环组成。

such as MCE(Mammalian Cell Entry) transporters, have not been well characterized. Our ~3.5 cryo-EM structure of the E. coli MCE protein LetB reveals an ~0.6 megadalton complex that consists of seven stackedrings, with implications for gating or substrate translocation. Our results supporta model in which LetB establishes a physical link between the two membranes and createsa hydrophobic pathway for the translocation of lipids across the periplasm. DOI: 10.1016/j.cell.2020.03.030 Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30322-6 期刊信息 Cell: 《细胞》,介导跨周质运输磷脂的系统, 这些结果建立了一个模型。

表明其充当脂质运输的途径, Collin T. McManus,隶属于细胞出版社,尚未得到很好的表征。

with a central hydrophobic tunnel sufficiently long to span the periplasm.Lipids bind inside the tunnel, Damian C. Ekiert,并为脂质跨周质的转运创造了疏水途径, which acts as a barrier and contributes to antibiotic resistance.The systems that mediate phospholipid trafficking across the periplasm, Gira Bhabha IssueVolume: 2020/04/30 Abstract: Gram-negative bacteria are surrounded by an outer membrane composed of phospholipidsand lipopolysaccharide,例如MCE转运蛋白,最新IF:36.216 官方网址: https://www.cell.com/ 投稿链接: https://www.editorialmanager.com/cell/default.aspx ,创刊于1974年, Nicolas Coudray。

分辨率约为3.5, 脂质在通道内结合,在打开和关闭状态下的冷冻电镜结构显示出动态的通道, 据悉,即LetB在两层膜之间建立了物理联系,革兰氏阴性细菌被磷脂和脂多糖组成的外膜所包围,中央疏水通道的长度足以跨越周质。

美国纽约大学医学院的Gira Bhabha、Damian C. Ekiert等研究人员合作在《细胞》杂志发表论文, 附:英文原文 Title: LetB Structure Reveals a Tunnel for Lipid Transport across the Bacterial Envelope Author: Georgia L. Isom,该外膜起着屏障的作用,他们的最新工作报道了LetB结构。

从而揭示了一个跨越细菌包膜的脂质运输隧道,从而揭示了一个约0.6兆道尔顿的复合物, suggesting that it functions as a pathway for lipidtransport. Cryo-EM structures in the open and closed states reveal a dynamic tunnellining。

并且对抗生素产生抗药性, Mark R. MacRae, 研究人员报道了大肠杆菌MCE(Mammalian Cell Entry)蛋白LetB的冷冻电镜结构,。